Week 9 Spread Picks: Ole Miss at Oklahoma, Vanderbilt vs. Missouri Lead SEC Betting Slate

A perennial SEC doormat, Vanderbilt would be a playoff team if the season ended today
CBS Sports notes Vanderbilt's surprising position ahead of its Week 9 game against one-loss Missouri.
Mark

Why does this week's slate matter beyond the betting lines?

Mimi

Because several of these games are really playoff eliminators. Ole Miss can afford only one more loss, and CBS says the Vanderbilt-Missouri winner could make the playoff while the loser doesn't.

Luke

Careful with that one. It's CBS's view of the possibilities, not a certainty. The article says there's a very real chance, not that it's settled.

Mark

Vanderbilt is the surprise here, right?

Mimi

Yes. They're described as a longtime SEC doormat, but they've lost only at Alabama and just beat a ranked LSU team, scoring 31 on a strong defense.

Luke

And the line of Vandy -2.5 is just one sportsbook's number, from DraftKings. The pick to win and cover is an opinion, not a result.

Mark

What about Ole Miss, coming off that Georgia collapse?

Mimi

They gave up 17 fourth-quarter points and lost. Now they're underdogs at Oklahoma, and CBS thinks the defense can rattle John Mateer, who is only three games back from injury.

Luke

That depends on Mateer's condition, which the piece doesn't detail. And the Kiffin and Florida job-opening talk is speculation about distraction, not reported fact.

Mark

Any other pick that hinges on a player?

Mimi

UCLA. Nico Iamaleava hurt his knee against Maryland, and his status is the main thing to monitor.

Luke

Right, we don't know yet whether he plays. Also, the Texas A&M at LSU pick is listed with no reasoning, so there's nothing to evaluate there.

  • Ole Miss carries the sting of a 17-0 fourth-quarter collapse into a road trip to Oklahoma, where one more loss could end its playoff hopes.
  • Vanderbilt, once an SEC doormat, is suddenly a playoff-caliber team, and its clash with Missouri could decide which one-loss club survives.
  • Oklahoma's status hangs on John Mateer, still working his way back from injury in only his third game since returning.
  • UCLA, surging under interim coach Tim Skipper, faces a 25.5-point spread at Indiana, with quarterback Nico Iamaleava's knee injury casting doubt over the outcome.

In the middle of a college football season that has already slipped past its early surprises, a handful of ranked teams are fighting not just for a result but for their place in the playoff picture. Ole Miss, still carrying the sting of a fourth-quarter collapse against Georgia, heads to Norman as a one-loss team that cannot afford another stumble, while Vanderbilt, a program long dismissed as an SEC afterthought, now finds itself imagined as a playoff team. Such weeks reveal how quickly reputations can turn, and how a single loss can change the entire shape of a season.

Last week Ole Miss held a late lead over Georgia and watched it slip away, getting outscored 17-0 in the fourth quarter. Now Lane Kiffin's team travels to Norman to face Oklahoma, and CBS Sports has them as a top Week 9 pick, taking the Rebels at +5.5. Both sides are one-loss College Football Playoff hopefuls who cannot easily absorb another defeat, and CBS expects Ole Miss to cover, especially if its defense can pressure John Mateer, who is only three games removed from injury.

The biggest pick on the slate may be Vanderbilt at -2.5 against Missouri. If the season ended today, Vanderbilt would be a playoff team, a striking notion for a program long seen as an SEC doormat. The Commodores' only loss came at Alabama, and they recently beat a ranked LSU team. The winner of this game could make the playoff while the loser does not, and CBS points to quarterback Diego Pavia as one of the country's best players.

Elsewhere, UCLA has rebounded from a 0-4 start to win three straight under interim coach Tim Skipper, and CBS likes the Bruins at +25.5 at Indiana. The key question is whether quarterback Nico Iamaleava's knee, hurt in the Maryland win, will allow him to play. In Chapel Hill, the picture is bleaker for North Carolina, which CBS sees as overmatched under Bill Belichick, and it takes ranked Virginia to cover a 10.5-point spread.

Last week, Ole Miss had a lead over Georgia late in the game and lost it. The Rebels were outscored 17-0 in the fourth quarter, which cost them the game and the spread bet. Now Lane Kiffin's team stays on the road, traveling to Norman to face Oklahoma, and CBS Sports has them as one of its top spread picks for Week 9 of the 2025 season, taking Ole Miss at +5.5.

The pick comes with a framing that the season has moved fast. It seems like days since Florida State upset Alabama and Ohio State beat Texas in Week 1, yet it is already Week 9, with College Football Playoff positioning being sorted out. Three SEC games this week have ranked teams on both sides, and all three are on CBS's list. All odds come from DraftKings Sportsbook.

The Ole Miss case is straightforward. The Rebels are still in good shape for the playoff but can afford only one more loss. Oklahoma is also a one-loss CFP hopeful, so this is a meeting of two teams that cannot easily absorb another defeat. CBS expects Ole Miss to cover, if not win outright, especially if its defense can pressure John Mateer, who is playing his third game back from injury for the Sooners. If Ole Miss falters, the piece says to expect more talk about Kiffin being distracted by the Florida job opening.

The biggest pick of the slate may be Vanderbilt at -2.5 against Missouri. CBS notes that if the season ended today, Vanderbilt would be a playoff team, a striking idea for a program long regarded as an SEC doormat. The Commodores' only loss came at Alabama. They just beat a ranked LSU team, scoring 31 points against a very good Tigers defense. Missouri also has one loss, also to Alabama. CBS sees a real chance that the winner makes the playoff and the loser does not. It points to quarterback Diego Pavia as one of the country's top players, says he and the Commodores have done special things at home, and picks Vandy to win and cover on Saturday.

Elsewhere, CBS likes UCLA at +25.5 at Indiana. The Bruins lost their first four games, then won three straight and are 3-1 under interim head coach Tim Skipper. They blew out Penn State and Michigan State and edged Maryland last week. Indiana, under Curt Cignetti, can score and run up margins, but CBS thinks 25.5 may be too many points. The key variable is quarterback Nico Iamaleava, who hurt his knee in the Maryland win.

The outlook is much different in Chapel Hill. CBS says the Bill Belichick experiment is not working, and North Carolina looks overmatched in ACC play. The Tar Heels are 2-4, with wins over Charlotte and Richmond, and have been blown out in three of their four losses. Virginia, which is ranked and chasing an ACC title, visits as a 10.5-point favorite, and CBS takes the Cavaliers. It points out that Clemson beat UNC by 28 on the road a few weeks ago. The list also includes Texas A&M at -2.5 at LSU, though the available text gives no analysis of that pick.

What to watch before kickoff: Mateer's condition for Oklahoma, and whether Iamaleava's knee allows him to play for UCLA, since either could change how those lines hold up.

There's a very real chance the winner of this game makes the CFP and the loser doesn't.
— CBS Sports
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