Three independent research teams — at the Broad Institute, the Wellcome Sanger Institute, and the Human Cancer Models Initiative — have published converging evidence that three-dimensional organoid models grown from patient tumors capture cancer biology that traditional flat cell cultures cannot. Across hundreds of models and ten or more cancer types, genome-scale CRISPR screens revealed genetic vulnerabilities that simply disappear when tumor cells are grown in a dish. The convergence is not merely technical; it marks a philosophical shift in how science chooses to represent living complexity