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POSITIVE Trial: Safe Pregnancy Pause During Breast Cancer Endocrine Therapy
Updated 71-month POSITIVE trial data confirm that premenopausal HR+ breast cancer patients can safely pause endocrine therapy to pursue pregnancy, with 76% achieving live births and no worsening of oncologic outcomes.
HIGH confidence
Young women with breast cancer previously faced a 5–10 year fertility delay due to endocrine therapy requirements, causing significant psychological and reproductive burden.
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