Prostate cancer has long confounded medicine not by its presence but by its unpredictability — two men, same mutations, vastly different fates. An international team sequencing 959 tumor genomes across seven countries has now identified eight distinct internal cellular processes responsible for DNA damage in 85 percent of cases, revealing that it is not which genes break but how these processes combine that determines whether a cancer sleeps or kills. The findings, published in Nature, suggest that prostate cancer is fundamentally a disease of cellular machinery failing from within, and that t