The spleen, long overlooked in the calculus of cardiac risk, may hold biological secrets that cholesterol panels and blood pressure cuffs cannot reach. Researchers at Mass General Brigham, working with AI and imaging data from tens of thousands of participants, have traced a thread from subtle structural features of the spleen to genetic variants long associated with coronary artery disease — the world's leading killer. The discovery does not overturn what medicine already knows, but it quietly expands the map, suggesting that inflammation, immune function, and cardiovascular fate may be more