Researchers develop retina model revealing how CLN3-Batten disease damages vision

Children with CLN3-Batten disease experience early vision loss affecting their ability to read, learn, and navigate independently, followed by progressive neurological decline.

Before a child with CLN3-Batten disease loses the ability to read a face or cross a room unassisted, something quiet and foundational is already failing deep within the eye. Researchers at the University of Rochester have built a three-dimensional retina from human stem cells to study this rare inherited condition, and what they found reframes the disease entirely: vision is not lost because light-sensing cells fail first, but because the support cells that sustain them collapse, taking everything built upon them down as well. In identifying a specific enzyme deficiency — acid ceramidase — as

Researchers develop retina model revealing how CLN3-Batten disease damages vision

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