KAIST Develops RNA Therapy to Block Cancer Cachexia, Extends Survival in Mice

Cancer cachexia affects 50-80% of cancer patients, causing severe physical decline and reducing treatment effectiveness, ultimately lowering survival rates.

For decades, cancer has claimed lives not only through its direct assault but through a secondary betrayal — the body consuming itself in a process called cachexia, which silently undermines treatment and survival in the majority of patients. Researchers at KAIST in South Korea have now traced this wasting to a precise molecular conversation in the brainstem, where a protein released by tumors instructs the body to break down its own muscle and fat. By silencing the receptor that receives this signal, their RNA-based therapy interrupted the cascade entirely — and in mouse studies, the differen

KAIST Develops RNA Therapy to Block Cancer Cachexia, Extends Survival in Mice

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