For those who live with the recurring darkness of chronic migraine, the search for relief has long pressed against the limits of what medicine can explain. A twelve-week clinical trial has now added a quiet but meaningful clue to that search: when migraine patients eliminated foods their immune systems flagged as reactive, measurable shifts occurred in their gut bacteria and in the proteins governing intestinal permeability — changes that did not appear in those who eliminated foods at random. The findings do not yet constitute a cure or even a confirmed mechanism, but they deepen the case tha