Endometriosis has long confounded medicine not merely because it is difficult to detect, but because it reliably returns. A study published in Nature now proposes that the disease's persistence may be rooted in how its misplaced cells generate energy — and that interrupting that energy supply, using a compound called Rotenone, can reduce lesions and scarring in experimental models. The finding reframes endometriosis as a metabolic condition as much as a hormonal or inflammatory one, opening a corridor of inquiry that conventional therapies have not yet entered.