Pancreatic cancer claims most of its victims not where it begins, but where it travels — and for decades, the molecular key enabling that journey has remained elusive. Researchers have now identified a protein called UNC5B as the central switch governing metastatic spread, demonstrating in mouse models that its absence completely halted tumor dissemination without affecting primary tumor growth. The discovery illuminates a specific molecular pathway — SRC to ZEB1 — through which cancer cells shed their identity and become wanderers, and raises the possibility that targeting this single protein