Two echinocandins show promise as eye infection treatments in animal study

Aspergillus fumigatus endophthalmitis can cause permanent vision loss and blindness if left untreated, making effective therapeutic options critical.

When a fungal infection takes hold inside the eye, it moves quickly toward blindness, and the drugs available to stop it have long been few. A new preclinical study now places two echinocandin compounds — rezafungin and anidulafungin — alongside the established treatments, suggesting that medicine's narrow corridor of options may be widening. The work, conducted in laboratory cultures and rabbit models, does not yet constitute a cure, but it marks the kind of careful threshold-crossing that eventually changes what physicians can offer their patients.

Two echinocandins show promise as eye infection treatments in animal study

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