Trained immunity emerges as key driver of diabetes and complications

For decades, diabetes has been understood as a failure of glucose regulation — a story told in blood sugar levels and insulin doses. But new research published in Genes & Diseases invites a deeper reckoning: the immune system itself, through a process called trained immunity, may be quietly amplifying the disease's most devastating consequences. When the body's first-responder immune cells become permanently primed by metabolic stress, they generate chronic inflammation that outlasts its original cause — suggesting that for millions living with diabetes, the battle is being fought on a front m