Study identifies three molecular subtypes of lung cancer in never-smokers

Lung cancer remains the leading cancer-related cause of death globally, affecting over 2 million people annually, with disproportionate impact on women and younger never-smokers.

Lung cancer has long worn the face of a smoker's disease, yet between one in ten and one in four diagnoses arrive without that history — a quiet mystery that science has struggled to explain. Researchers at the U.S. National Cancer Institute, publishing in Nature Genetics, have now traced most of these tumors to the body's own interior processes: the slow, inevitable accumulation of mutations that arise from faulty DNA repair and oxidative stress, not from the world outside. By identifying three distinct molecular subtypes — each with its own pace, genetic signature, and vulnerability — the st

Study identifies three molecular subtypes of lung cancer in never-smokers

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