In the long human struggle to understand why healthy cells turn against the body, a new study published in Nature offers a rare glimpse into the earliest moments of prostate cancer's emergence. Using CRISPR technology to introduce the human SKP2 gene into mouse prostate tissue, researchers watched a single overexpressed protein quietly dismantle both cellular order and immune vigilance — transforming normal tissue into a landscape hospitable to cancer. The work matters not only for what it reveals about disease initiation, but for the organoid-based tools it leaves behind, tools that may one d