Scientists Reverse Kidney Injury in Mice by Blocking Ceramide Damage

Acute kidney injury affects hospitalized patients and ICU patients, increasing risk of chronic kidney disease with limited treatment options.

The kidneys, those tireless and unheralded organs, have long surrendered their patients to a condition with few remedies — acute kidney injury, a sudden collapse of filtration that shadows ICU wards and opens the door to lifelong disease. Now, researchers in the United States have identified a molecular culprit — ceramide lipids that sabotage the mitochondria of kidney cells — and demonstrated, in mice, that blocking these molecules can prevent and potentially reverse the injury entirely. The finding, published in Cell Metabolism, does not yet reach the bedside, but it offers something medicin

Scientists Reverse Kidney Injury in Mice by Blocking Ceramide Damage

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