Buried within the genome's vast regulatory landscape, scientists have long suspected that the switches controlling genes matter as much as the genes themselves. A team at USC's Keck School of Medicine has now confirmed, in prostate cancer cells, that these switches are not scattered and independent but organized into three-dimensional hierarchies — with master nodes capable of silencing entire networks of cancer-driving genes when removed. The discovery, published in Genome Biology, suggests that future therapies might one day edit a single control point to quiet many tumors at once, though th