The heart does not simply wear out with age — it undergoes a precise, cascading series of molecular failures, each one compounding the last. A new review in Cardiovascular Innovations and Applications maps these mechanisms with unusual clarity, tracing how mitochondrial dysfunction, chronic inflammation, cellular senescence, and epigenetic drift converge to make aging hearts increasingly vulnerable. In doing so, it also surveys the growing arsenal of interventions — from lifestyle changes to AI-guided precision medicine — that may slow the progression. It is not a promise of immortality, but a