Protein RAGE Linked to Aggressive Breast Cancer in Older Adults

For decades, clinicians have observed that breast cancer claims older lives with particular ferocity, yet the biological reason remained elusive. Researchers at Georgetown University's Lombardi Comprehensive Cancer Center have now identified a protein called RAGE as a central architect of this disparity — a molecular receptor that grows more active with age, stoking chronic inflammation and quietly preparing the body to receive and sustain metastatic disease. The discovery reframes a long-standing question: it is not only the tumor that determines fate, but the aging landscape in which it grow