Among the most common hormonal disorders of reproductive-age women, polycystic ovary syndrome has long been understood as a condition of fertility and metabolism — but a sweeping two-decade study of more than 413,000 American women now places it firmly in the territory of the heart. Published in The Lancet, the research reveals that women with PCOS face roughly four times the cardiovascular risk of those without it, a danger that persists even after accounting for obesity, diabetes, and other familiar culprits. The finding suggests that PCOS carries within it some deeper biological signature —
PCOS linked to fourfold higher heart disease risk in women, study finds
Women with PCOS face significantly elevated cardiovascular mortality and morbidity risk, affecting reproductive-age populations with long-term health consequences.