Pancreatic tumor microenvironment blocks ferroptosis through HIF-2 pathway

Pancreatic ductal adenocarcinoma carries a median life expectancy of less than one year following diagnosis despite treatment.

Pancreatic cancer has long defied the logic of its own biology — carrying mutations that should invite cell death, yet surviving with grim efficiency. Researchers at the Ludwig Institute and Johns Hopkins have now traced this paradox to the tumor's oxygen-starved interior, where a protein called HIF-2 quietly constructs a multi-layered shield against ferroptosis, a form of iron-driven cellular destruction. The discovery reframes the disease not merely as a genetic problem but as an environmental one, suggesting that the tumor's hostile microenvironment is itself a therapeutic target. For patie

Pancreatic tumor microenvironment blocks ferroptosis through HIF-2 pathway

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