For generations, oncology has operated on a simple axiom: more is more. A study now published in Nature quietly unsettles that assumption, demonstrating that certain cancer immunotherapy antibodies follow a bell-shaped logic — where exceeding an optimal dose does not amplify the cure, but diminishes it. The research, centered on TNFR2-targeting antibodies tested in cell lines and primates, suggests that the search for a maximum tolerated dose may sometimes lead clinicians away from the dose that actually heals.