Heart failure triggers brain cell senescence pathway linked to cognitive decline

For the millions living with heart failure, cognitive decline has long been attributed to a simple shortage of blood reaching the brain — but science now reveals a second, more intimate betrayal. Researchers have traced a molecular chain of events in which the failing heart dispatches chemical signals that prematurely age the brain's blood vessel cells, which in turn recruit immune cells to consume the very synaptic connections that sustain thought and memory. The discovery, emerging from mouse models engineered to mirror human heart failure, identifies not one but several points along this pa