DNA methylation changes linked to lung spread in triple-negative breast cancer

Triple-negative breast cancer carries one of oncology's most sobering prognoses, and its tendency to colonize the lungs has long resisted explanation. A new study published in Nature Communications illuminates a hidden layer of that story — not in the genes themselves, but in the chemical annotations that govern them, revealing how a systematic rewriting of the epigenome appears to escort cancer from its origin into distant tissue. By identifying three genes whose expression in primary tumors anticipates lung spread, researchers have placed a potential early-warning instrument in the hands of