D&D-seq Maps DNA-Protein Interactions in Single Cells Using Base Editing

For decades, the molecular conversations between proteins and DNA — the fleeting contacts that decide a cell's fate — have slipped through the fingers of even the most sophisticated laboratory methods. A new technique called D&D-seq, published in Cell, transforms DNA itself into a living record of these interactions, capturing them at the resolution of a single cell. By chemically inscribing the moment a regulatory protein touches the genome, researchers can now read the regulatory biography of individual cells rather than the blurred average of millions — a shift that carries profound implica