Severe menstrual cramps may signal endometriosis, affecting 180M women globally

Endometriosis affects over 180 million women globally, causing chronic pain, infertility risks, and significant quality-of-life impacts including sexual dysfunction and psychological stress.
Severe pain is not a symptom of menstruation; it is a warning
Gynecologists emphasize that debilitating cramps signal endometriosis, not normal menstrual discomfort.

Across the world, more than 180 million women carry a condition that medicine has long struggled to name in time — endometriosis, a disease in which the body turns against itself, growing uterine tissue where it does not belong and answering each menstrual cycle with inflammation, scarring, and pain. Too often, this suffering is absorbed in silence, mistaken for the ordinary discomfort of womanhood rather than recognized as a signal demanding care. Specialists now urge that severe menstrual pain is never simply a burden to be endured, and that early diagnosis can mean the difference between a manageable life and one defined by chronic loss.

  • Cólicas tão intensas que impedem o trabalho, o movimento e o descanso não são normais — são um alerta que médicos dizem ser ignorado com frequência perigosa.
  • A endometriose afeta 1 em cada 10 mulheres no mundo e no Brasil, mas segue sendo confundida com desconforto menstrual comum, atrasando diagnósticos por anos.
  • Além da dor pélvica, a doença pode causar sangramento intestinal, desconforto urinário e dor durante relações sexuais, corroendo silenciosamente a qualidade de vida.
  • A infertilidade é uma consequência real: a inflamação cria um ambiente hostil à gestação, e tratar a doença antes de tentar engravidar é considerado essencial pelos especialistas.
  • Embora sem cura definitiva, o diagnóstico precoce abre caminho para tratamentos cirúrgicos e clínicos que controlam os sintomas, preservam a fertilidade e devolvem autonomia às mulheres.

Quando a menstruação traz uma dor tão intensa que impede o trabalho e o movimento cotidiano, algo está errado. Esse sinal pode indicar endometriose — condição que afeta mais de 180 milhões de mulheres no mundo, segundo a Organização Mundial da Saúde. Uma em cada dez mulheres vive com ela globalmente; no Brasil, o índice chega a dez por cento da população feminina. Ainda assim, a doença é amplamente mal compreendida e frequentemente descartada como simples desconforto menstrual.

A endometriose ocorre quando o tecido que normalmente reveste o interior do útero cresce fora dele — na cavidade pélvica, nos intestinos, na bexiga. Esse tecido responde aos mesmos sinais hormonais do ciclo menstrual: engrossa e sangra, mas o sangue não tem para onde ir. O resultado é inflamação, cicatrizes e aderências que podem unir órgãos. Os sintomas vão além das cólicas: sangramento nas fezes durante a menstruação, desconforto urinário, dor durante relações sexuais. O ginecologista Alexandre Silva e Silva ressalta que esses não são variações normais da menstruação — são avisos que exigem atenção.

A doença costuma surgir entre os 25 e os 35 anos, mas pode afetar qualquer mulher em idade reprodutiva. Suas origens ainda intrigam a medicina: a teoria do refluxo menstrual foi questionada pela descoberta da condição em fetos, e hoje se acredita que algumas mulheres nascem com predisposição, agravada por fatores como sedentarismo, obesidade e uso de anticoncepcionais combinados.

Para quem deseja engravidar, os riscos são ainda maiores. A endometriose é uma das principais causas de infertilidade feminina, e o ginecologista Domingos Mantelli alerta que tratar a doença antes de buscar a gestação é fundamental. O diagnóstico envolve exames de sangue, ressonância magnética pélvica e ultrassom transvaginal. Quanto mais cedo identificada, maiores as chances de sucesso cirúrgico.

Não há cura permanente, mas há tratamento. Anticoncepcionais de progesterona isolada e anti-inflamatórios controlam os sintomas clinicamente. A cirurgia remove as lesões visíveis. Para mulheres mais jovens, a ressecção do tecido é indicada; para aquelas que planejam engravidar, pode-se optar por congelar óvulos antes da operação, já que o procedimento em si carrega risco de infertilidade. O objetivo é gerenciar a doença, preservar a fertilidade e devolver a possibilidade de uma vida sem dor crônica.

When a woman's period brings pain so severe that she cannot work, cannot sit comfortably, cannot move through her day as she normally would, something is wrong. This is not the ordinary cramping that many women experience. This is a signal—one that gynecologists say too many women ignore or accept as inevitable.

That signal may point to endometriosis, a condition affecting more than 180 million women worldwide according to World Health Organization estimates. One in ten women globally lives with it. In Brazil, the figure reaches ten percent of the female population. Yet the disease remains widely misunderstood, often dismissed as severe menstrual discomfort rather than recognized as the inflammatory condition it is.

Endometriosis occurs when tissue that normally lines the inside of the uterus grows where it should not—in the pelvic cavity, on the intestines, in the bladder, anywhere beyond the uterine wall. This misplaced tissue responds to the same hormonal signals as the tissue inside the uterus. During the menstrual cycle, it thickens and bleeds just as the uterine lining does. But the blood has nowhere to go. It pools in the pelvic cavity, irritating the membrane that lines the abdomen and pelvis, triggering inflammation, scarring, and the formation of adhesions—bands of scar tissue that bind organs together. The result is pain that can be debilitating.

The symptoms extend far beyond cramping. Women with endometriosis may experience bleeding in their stool during menstruation or pain during bowel movements. Some notice blood in their urine or discomfort when urinating around their period. Sexual intercourse becomes painful, particularly deep penetration. The condition erodes quality of life in ways that ripple outward—chronic pain feeds stress, stress compounds the physical symptoms, and the cycle deepens. Gynecologist Alexandre Silva e Silva notes that these are not normal variations of menstruation; they are warnings that demand attention.

The disease typically emerges between ages 25 and 35, though it can develop in any woman of reproductive age. Its origins remain mysterious. Doctors once believed that menstrual blood flowed backward into the pelvis, seeding the tissue in wrong places. But the discovery of endometriosis in fetuses upended that theory. Current thinking suggests that some women are born with a predisposition to the condition, one that may be triggered or worsened by lifestyle factors: lack of physical activity, obesity, inflammatory diet, and use of combined hormonal contraceptives containing both progesterone and estrogen.

The stakes are particularly high for women hoping to conceive. Endometriosis is a leading cause of female infertility. The inflammation creates a hostile environment for embryo implantation. Even when pregnancy occurs, the risk of miscarriage is elevated. Gynecologist Domingos Mantelli emphasizes that women who want to become pregnant must treat the disease first; pursuing fertility treatment without addressing endometriosis can lead to successful conception followed by loss.

Diagnosis requires multiple tools: blood tests measuring CA-125, an indicator of the disease; pelvic magnetic resonance imaging; and transvaginal ultrasound with bowel preparation. Early detection matters enormously. The earlier endometriosis is identified, the better the chance that surgery can remove all lesions and offer a cure. Advanced stages carry lower cure rates.

There is no permanent cure, but treatment exists. Clinical approaches involve stopping menstruation through progesterone-only contraceptives and anti-inflammatory medications. Surgery removes visible lesions. For younger women, surgery is often recommended to resect the endometrial tissue. For older women planning pregnancy, the approach differs: doctors may freeze eggs or embryos through in vitro fertilization before operating, since surgery itself carries a risk of causing infertility. The goal is not to erase the disease entirely but to manage it, preserve fertility, and restore the possibility of a life without chronic pain.

When cramps become unbearable, it is a warning sign that something is not right
— Gynecologist Alexandre Silva e Silva
Women who want to become pregnant must treat endometriosis first; pursuing fertility treatment without addressing it can lead to pregnancy loss
— Gynecologist Domingos Mantelli
La Conversación del Hearth Otra perspectiva de la historia
Inventor

Why does endometriosis get missed so often? Women have been having painful periods forever.

Model

Because we've normalized it. A woman says her cramps are unbearable, and she's told that's just how periods are. But there's a difference between discomfort and pain that stops you from functioning. Doctors now understand that severe pain is a symptom, not a feature.

Inventor

The source mentions that endometriosis was found in fetuses. What does that tell us?

Model

It means the disease isn't simply caused by what happens during menstruation—it's not just backward flow of blood. Some women appear to be born with the tissue already in the wrong place, or with a genetic vulnerability. That's why lifestyle factors matter so much; they may activate something that was already there.

Inventor

If there's no cure, what's the point of early diagnosis?

Model

The point is surgery. If you catch it early, a surgeon can remove all the lesions and potentially cure you. Wait until the disease has spread and scarred extensively, and removal becomes much harder. Early diagnosis is the difference between cure and lifelong management.

Inventor

The article mentions infertility. Is that reversible?

Model

Sometimes. If you treat the endometriosis before trying to conceive, you improve your chances. But the inflammation itself makes pregnancy harder, and miscarriage risk stays high. That's why doctors tell women: treat first, then plan pregnancy.

Inventor

What about the lifestyle factors—obesity, lack of exercise, inflammatory diet?

Model

They're contributors, not causes. A woman doesn't get endometriosis because she's sedentary. But inflammation feeds the disease, so reducing inflammatory triggers through diet and activity may slow progression or reduce symptoms. It's management, not prevention.

Inventor

So a woman with endometriosis lives with this forever?

Model

Not necessarily forever, but yes, likely for years. Surgery can remove lesions, but they can return. Medication can suppress symptoms. The goal shifts from cure to control—keeping the disease from advancing, preserving fertility, and letting her live without constant pain.

Contáctanos FAQ