In the relentless drive to grow, cancer cells push their own genetic machinery past the point of stability—and new research from Hebrew University of Jerusalem reveals that this self-imposed strain causes repeated DNA breaks in the very regions that sustain malignancy. Each cycle of damage and repair quietly accumulates errors, offering tumors a path toward greater adaptability and resistance. Yet what makes cancer formidable may also make it fragile: the same high-stress regions that fuel its growth could become the sites of its undoing.