For generations, medicine has hoped that the brain's architecture might reveal its disorders as plainly as a broken bone reveals itself on an X-ray. A large new analysis, published in Nature Neuroscience and led by researchers at Monash University, quietly dismantles that hope for autism, depression, and bipolar disorder — finding that structural MRI scans produce no consistent, reproducible signatures across independent studies for these conditions. Where Alzheimer's disease speaks clearly in brain images, psychiatric illness, it seems, speaks in many voices at once, and no single picture cap